Absolute 0.2 Micron Filter Cartridge for Sterile Filtration
High Quality Membrane Filter Cartridge Supplier in China
Absolute 0.2 Micron Filter Cartridge
The Absolute 0.2 Micron Filter Cartridge operates on the principle of size-exclusion filtration. As fluid passes through the pleated membrane, particles and microorganisms larger than 0.2 μm are captured on the membrane surface or within its depth.
Surface Retention: Larger bacteria and particles are physically blocked at the surface.
Depth Capture: Smaller colloids and fine particles are trapped within the membrane’s porous structure.
Sterile Assurance: No viable bacteria can pass through, as validated by microbial challenge testing with B. diminuta.
The pleated structure allows high throughput while maintaining low pressure drop, making the cartridge suitable for both high-volume industrial systems and laboratory-scale applications.
Introduction of Absolute 0.2 Micron Water Filter Cartridge
Sterile filtration is one of the most critical processes in industries where product safety, purity, and reliability cannot be compromised. Whether in pharmaceutical manufacturing, biotechnology laboratories, food and beverage production, or advanced water treatment, the need to ensure absolute microbial retention is paramount. The Absolute 0.2 Micron Filter Cartridge for Sterile Filtration is engineered to meet these challenges with precision, delivering consistent results, validated performance, and superior structural integrity.
Unlike nominal filters, which provide only partial retention, absolute-rated cartridges guarantee that particles and microorganisms of a specified size—0.2 microns in this case—are completely removed. This distinction is vital when sterile conditions must be maintained, particularly for injectable drugs, bioreactor feeds, ultrapure water, and sensitive beverage formulations.
This product page provides a comprehensive overview of the Absolute 0.2 Micron Filter Cartridge, covering its construction, features, working principle, technical advantages, and diverse applications across multiple industries.
Why Choose an Absolute 0.2 Micron Filter Cartridge?
Before examining the specific product details, it is important to understand the significance of the 0.2 micron absolute rating. In filtration science, 0.2 μm has become the recognized standard for removing bacteria such as Brevundimonas diminuta, a challenge organism commonly used in validation testing. A filter that can effectively retain these microorganisms is considered reliable for sterilizing-grade applications.
Key Benefits of the 0.2 Micron Absolute Rating:
Microbial Safety
Provides sterile-grade retention, preventing the passage of harmful bacteria and ensuring safe end products.
Regulatory Compliance
Meets global standards such as FDA, USP, and ISO requirements for pharmaceutical and food-grade applications.
Process Consistency
Absolute-rated membranes deliver predictable retention, reducing batch-to-batch variation.
High Confidence in Validation
Each cartridge can be integrity-tested using methods such as bubble point, diffusion, or pressure decay tests, offering assurance of performance prior to use.
Construction and Materials
The Absolute 0.2 Micron Filter Cartridge is designed using advanced pleated membrane technology, ensuring both high surface area and efficient particle retention.
Typical Construction Elements:
Filter Media:
Polyethersulfone (PES), Polyvinylidene Fluoride (PVDF), or Nylon 66 membranes are commonly used for sterile-grade applications due to their hydrophilic properties and chemical resistance.
Support Layers:
Non-woven polypropylene or polyester layers for added mechanical strength.
Core and Cage:
Rigid polypropylene, stainless steel, or reinforced nylon options for structural integrity under high pressure.
End Caps:
Thermal-bonded polypropylene, eliminating adhesives or glues that could leach contaminants.
Seals/Gaskets:
EPDM, silicone, Viton®, or PTFE O-rings to ensure leak-free installation in filter housings.
The cartridge is available in various lengths (5″, 10″, 20″, 30″, 40″) and diameters, compatible with industry-standard housings.
Features of the 0.2 Micron Absolute Filter Cartridge
Absolute-rated membrane filtration at 0.2 μm for sterile assurance.
Pleated design that maximizes surface area and extends service life.
High dirt-holding capacity, reducing the frequency of replacement and minimizing downtime.
Low pressure drop, ensuring energy efficiency and high flow rates.
Broad chemical compatibility, suitable for a wide range of solvents, buffers, and cleaning agents.
Thermally welded construction, ensuring cleanliness with no adhesives or extractables.
Integrity testable, allowing verification before and after use.
Compliance with international standards such as USP <85> (bacterial endotoxins), USP <788> (particulate matter), and FDA CFR 21 regulations.
Advantages Over Conventional Filters
Compared with nominal-rated or depth-type filters, the Absolute 0.2 Micron Cartridge Filter offers significant advantages:
Absolute Retention
Guarantees microbial safety, unlike nominal filters that may allow variable particle passage.
Extended Service Life
Pleated membrane provides a greater filtration area, handling higher contaminant loads before clogging.
Operational Efficiency
Reduces energy costs by maintaining low differential pressure across the filter.
Enhanced Compatibility
Resistant to a wide variety of chemicals, solvents, and sanitization procedures (e.g., autoclaving, gamma irradiation, CIP/SIP).
Validated Sterile Filtration
Tested and certified using globally recognized microbial challenge standards.
Technical Advantages in Sterile Filtration
Integrity Testing Support: The cartridge supports bubble point, diffusion, and pressure decay tests to confirm retention capability before critical use.
Autoclavable & Steam Sterilizable: Capable of withstanding multiple sterilization cycles without degradation.
Low Extractables: Ensures that no harmful substances leach into sensitive products like injectables or beverages.
Scalability: Available in laboratory capsule filters, pilot-scale filters, and full-scale cartridge formats for seamless process scale-up.
Filter Cartridges in Petroleum and Chemical Industries
Microelectronics Industry
Water Treatment Industry
Food And Beverage Industry
Applications of Our 0.2um Filter Cartridges
The Absolute 0.2 Micron Filter Cartridge is engineered for industries where sterile assurance and high purity are critical. In the pharmaceutical sector, it ensures safe injectable solutions, sterile feeds for bioreactors, final product sterilization, and protection of protein-based drugs. For biotechnology and laboratories, it secures sterile media, buffers, and reagents for cell culture, molecular biology, and research workflows. In the food and beverage industry, it safeguards product quality by removing spoilage organisms from beer, wine, dairy, bottled water, juices, and soft drinks. The cartridge also supports microelectronics and ultrapure water systems, protecting semiconductor manufacturing and laboratory-grade water purity. Additionally, in healthcare and medical devices, it enables sterile water for injection, dialysis water treatment, and device cleaning. With reliable bacterial retention, broad compatibility, and validated performance, the Absolute 0.2 Micron Filter Cartridge is a trusted solution across multiple critical applications.
Specification of 0.2um Filter Cartridge
| Parameter | Value/Description |
|---|---|
| Filter Media | PES (Polyethersulfone), PVDF, or Nylon 66 |
| Pore Size Rating | Absolute 0.2 μm |
| Construction | Pleated membrane with polypropylene support |
| Length Options | 5″, 10″, 20″, 30″, 40″ |
| Outer Diameter | Standard 2.75″ (70 mm) or custom options |
| End Cap Configurations | DOE, 222/Flat, 222/Fin, 226/Flat, 226/Fin |
| Seals/Gaskets | EPDM, Silicone, Viton®, PTFE |
| Maximum Operating Pressure | Up to 5.5 bar (80 psi) @ 25°C |
| Operating Temperature | 4°C to 80°C (continuous operation) |
| Sterilization | Autoclave at 121°C, Steam-in-place at 125°C |
| Integrity Testing | Bubble Point, Diffusion, Pressure Hold Test |
| Compliance | USP <85>, USP <788>, FDA CFR 21, ISO 13485 |
| Typical Flow Rate | ≥ 25 L/min for water at 0.2 bar, 10″ length |
Our Quality Control for Absolute Cartridge Filter 0.2 Micron Manufacturing
Our pleated filter cartridges are produced in ISO Class 8 cleanrooms to ensure contamination-free manufacturing and superior product purity.
Each filter cartridge undergoes rigorous quality control, including bubble point testing, integrity testing, and flow rate verification to ensure consistent performance and compliance with international standards.
We utilize advanced automated equipment for pleating, welding, and assembly processes. This ensures precise manufacturing, consistent quality, and high production efficiency while minimizing manual errors and contamination risks.
Performance Data
The Absolute 0.2 Micron Filter Cartridge is validated for sterile filtration using microbial challenge testing.
Test Organism: Brevundimonas diminuta (ATCC 19146)
Challenge Level: 1 x 10⁷ CFU/cm² effective filtration area
Result: Complete retention, confirming sterile-grade performance.
Comparative Filtration Capabilities
| Cartridge Type | Particle/Bacteria Retention | Typical Application |
|---|---|---|
| 5 Micron Filter Cartridge | Removes visible particles, rust, silt | Whole-house filtration, pre-filtration |
| 0.45 Micron Filter Cartridge | Retains fine particles, some bacteria | Beverage clarification, pre-sterile step |
| 0.2 Micron Filter Cartridge | Absolute retention of bacteria (B. diminuta) | Pharmaceutical sterilization, biotech, food & beverage sterile processing |
Frequently Asked Questions (FAQ)
Q1: What does “absolute 0.2 micron” mean?
A1: Absolute rating guarantees that all particles equal to or larger than 0.2 μm are retained, as validated by microbial challenge testing. This is different from nominal filters, which only capture a percentage of particles.
Q2: Can the filter cartridge be reused?
A2: While the filter is designed for single-use critical applications, it can withstand multiple steam or autoclave cycles when used in non-critical processes.
Q3: How is the filter tested for integrity?
A3: Each cartridge can be tested using bubble point, pressure decay, or diffusive flow tests to confirm microbial retention capability before and after use.
Q4: What is the difference between 0.2 μm and 0.22 μm cartridges?
A4: Functionally, both provide sterile retention. 0.22 μm is often used interchangeably, though 0.2 μm may be specified in certain regulatory or process requirements.
Q5: What housings are compatible with this cartridge?
A5: The cartridge fits standard 10″–40″ industry housings with 222, 226, or DOE end cap configurations.
Ordering and Customization
Customers can order the Absolute 0.2 Micron Filter Cartridge in standard sizes or request customized specifications. Options include:
Length: 5″ to 40″
Media Type: PES, PVDF, Nylon 66
End Cap Configurations: DOE, 222/Fin, 222/Flat, 226/Fin, 226/Flat
Seal Materials: EPDM, Silicone, Viton®, PTFE
Special Packaging: Cleanroom double-bagged for sterile assurance
Minimum order quantities, lead times, and bulk purchase discounts are available upon request.
Conclusion
The Absolute 0.2 Micron Filter Cartridge for Sterile Filtration represents the highest standard of microbial safety and process reliability. Designed with advanced pleated membrane technology, it provides unmatched sterile assurance, regulatory compliance, and long operational life. Whether in pharmaceutical manufacturing, biotechnology laboratories, food and beverage production, or high-purity water systems, this filter cartridge delivers validated, reproducible, and efficient sterile filtration.
For industries where contamination is not an option, this cartridge offers peace of mind and process consistency. By choosing an Absolute 0.2 Micron Filter Cartridge, companies safeguard product quality, protect end users, and ensure compliance with the most demanding regulatory standards.
Contact Us
nterested in our high-quality PES pleated filter cartridges? Whether you need bulk supply or custom designs, our expert team is ready to assist. Get in touch for product catalogs, free samples, or a tailored quotation.
Email: john@econefiltration.com
Website: econefiltration.com
Phone/WhatsApp: +86-15057941949
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